（一）个人基本情况
温栾， 生物化学与分子生物学专业博士，教授职称，研究领域为甲状腺素在发育与代谢中的分子机制与转化研究，现就职于生物化学与分子生物学教研室。
（二）教育背景：
2000年9月至2004年6月，就读于中国农业大学生物工程专业，获学士学位；
2005年9月至2010年7月，就读于中国科学院大学广州生物医药与健康研究院生物化学与分子生物学专业，获博士学位；
（三）教学与科研成果
1、主持的项目
例如：
1. 甲状腺素受体调节Inhbb在后胚胎期大脑发育中的功能及机制研究、822RC691、海南省科技厅、2022/04-2024/04、10万；
2. 甲状腺素受体调节pim3在小肠后胚胎期发育中功能及机制研究、32160173、国家自然科学基金委、2022/01-2025-12、34万；
3. 大肠杆菌基因组的理性设计与化学合成、2018YFA0903702、科技部重点研发合成生物学专项、2019/07-2024/06、336万；
2、代表性论文/专著、参编教材等
Wen, L.,*# Zhao, C.,# Song J., Ma L., Ruan, J., Xia X.,, Chen E. Y., Zhang, J., Ma, P. X., Xu J.*（2020）.CRISPR/Cas9 mediated TERT disruption in cancer cells. Int. J. Mol. Sci. 21, 653. *共同通讯 # 共同一作（IF5.923）
Wen, L., He, C., Sifuentes, C. J., & Denver R. J. (2019). Thyroid hormone receptor alpha is required for thyroid hormone-dependent neural cell proliferation during tadpole metamorphosis. Frontiers in Endocrinology. 10:396 （IF5.555）
Wen, L., Fu, L., & Shi, Y. B. (2017). Histone methyltransferase Dot1L is a coactivator for thyroid hormone receptor during Xenopus development. The FASEB Journal, 31(11), 4821-4831. （IF5.595）
Wen, L., Shibata, Y., Su, D., Fu, L., Luu, N., & Shi, Y. B. (2017). Thyroid hormone receptor α controls developmental timing and regulates the rate and coordination of tissue-specific metamorphosis in Xenopus tropicalis. Endocrinology, 158(6), 1985-1998. （IF4.286）
Wen, L., & Shi, Y. B. (2016). Regulation of growth rate and developmental timing by Xenopus thyroid hormone receptor α. Development growth & differentiation, 58(1), 106-115. （IF2.142）
Wen, L., Hasebe, T., Miller, T. C., Ishizuya-Oka, A., & Shi, Y. B. (2015). A requirement for hedgehog signaling in thyroid hormone-induced postembryonic intestinal remodeling. Cell & bioscience, 5, 13. （IF7.13）
Wen, L., & Shi, Y. B. (2015). Unliganded thyroid hormone receptor α controls developmental timing in Xenopus tropicalis. Endocrinology, 156(2), 721-734. （IF4.97）
Wen, L., Fu, L., Guo, X., Chen, Y., & Shi, Y. B. (2015). Histone methyltransferase Dot1L plays a role in postembryonic development in Xenopus tropicalis. The FASEB Journal, 29(2), 385-393. （IF5.32）
Wen, L., Yang, Y., Wang, Y., Xu, A., Wu, D., & Chen, Y. (2010). Appl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells. Developmental Dynamics, 239(8), 2198-2207. （IF2.970）
Wen, L., Liu, J., Chen, Y., & Wu, D. (2010). Identification and preliminary functional analysis of alternative splicing of Siah1 in Xenopus laevis. Biochemical and biophysical research communications, 396(2), 419-424. （IF2.846）
Okada, M.*, Wen, L.*, Miller, T. C., Su, D., & Shi, Y. B. (2015). Molecular and cytological analyses reveal distinct transformations of intestinal epithelial cells during Xenopus metamorphosis. Cell & bioscience, 5, 74. (* 共同一作 ) （IF7.13）
Luu, N.*, Wen, L.*, Fu, L., Fujimoto, K., Shi, Y. B., & Sun, G. (2013). Differential regulation of two histidine ammonia-lyase genes during Xenopus development implicates distinct functions during thyroid hormone-induced formation of adult stem cells. Cell & bioscience, 3, 43. (* 共同一作) （IF7.13）
Song, J., Hoenerhoff, M., Yang, D., Yang, Y., Deng, C., Wen, L., Ma, L., Pallas, B., Zhao, C., Koike, Y., Koike, T., Lester, P., Yang, B., Zhang, J., Chen, Y., Xu, J. (2021) Development of the Nude Rabbit Model, Stem Cell Reports, 16, (3), 656-665 (IF7.765)
Xiang L., Li G., Wen L., Su C., Liu Y., Tang H., Dai J. (2021) Biodegradation of aromatic pollutants meets synthetic biology. Synth Syst Biotechnol., 6(3):153-162. (IF4.33)
Ma, L., Ruan, J., Song, J., Wen, L., Yang, D., Zhao, J. & Xu, J. (2020). MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits. Nature Communications, 11(1), 1-11. （IF12.121）
Shibata, Y., Wen, L., Okada, M., & Shi, Y. B. (2019). Organ-specific requirements for thyroid hormone receptor ensure temporal coordination of tissue-specific transformations and completion of xenopus metamorphosis. Thyroid, 30 (2), 300-313. （IF7.786）
Fu, L., Wen, L., & Shi, Y. B. (2018). Role of thyroid hormone receptor in amphibian development. Methods Mol Biol. 1801:247-263. （IF10.71）
Okada, M., Miller, T. C., Wen, L., & Shi, Y. B. (2017). A balance of Mad and Myc expression dictates larval cell apoptosis and adult stem cell development during Xenopus intestinal metamorphosis. Cell death & disease, 8(5), e2787. （IF6.304）
Fu, L., Wen, L., Luu, N., & Shi, Y. B. (2016). A simple and efficient method to visualize and quantify the efficiency of chromosomal mutations from genome editing. Scientific Reports, 6. （IF3.998）
Kyono, Y., Sachs, L. M., Bilesimo, P., Wen, L., & Denver, R. J. (2016). Developmental and thyroid hormone regulation of the DNA methyltransferase 3a gene in Xenopus tadpoles. Endocrinology, 157(12), 4961-4972. （IF4.286）
Sun, G., Fu, L., Wen, L., & Shi, Y. B. (2014). Activation of Sox3 gene by thyroid hormone in the developing adult intestinal stem cell during Xenopus metamorphosis. Endocrinology, 155(12), 5024-5032. （IF4.644）
学术经历及社会服务
工作经历
2018年7月至2021年3月，任中国科学院深圳先进技术研究院副研究员
海外经历
2011年4月-2016年2月，美国国立卫生研究院单位，博士后
2016年3月-2018年7月，美国密歇根大学，博士后
