旷代(PhD),副研究员,mg4355线路检测官网(海南省医学科学院)热带医学院临床病原生物学检验教研室暨国家卫生健康委热带病防治重点实验室成员,海南自由贸易港D类高层次人才(拔尖人才)。上海交通大学医学院附属瑞金医院呼吸与危重症医学科博士后,上海交通大学生命科学技术学院和美国马里兰大学营养与食品科学系联合培养博士。主要从事条件致病菌尤其是肺炎克雷伯菌、沙门氏菌和类鼻疽伯克霍尔德菌的群体基因组学、耐药和传播机制以及致病机制等方向的研究。主持国家自然科学基金青年项目一项,作为主要参与人参与国家重点研发专项和国际合作项目多项;目前担任中国研究型医院学会微生物感染与转化专业委员会青年委员,Frontiers in Microbiology杂志Review Editor(编委成员),Journal of Antimicrobial Chemotherapy和Foodborne Pathogens and Disease等多个SCI杂志审稿专家。
联系方式
Email: daikuang@hainmc.edu.cn
通讯地址:海南省海口市龙华区学院路3号mg4355线路检测官网,571199
研究领域
(1)细菌耐药产生和传播以及致病机制研究
(2)细菌群体基因组和可移动基因组研究
(3)常见条件致病菌的的快速检测技术开发研究
课程教学
热带医学概论,临床分子生物学诊断技术,临床微生物学及检验,临床寄生虫学及检验
科研项目
(1)国家自然科学基金青年项目,82000011,CRISPR/Cas系统调控肺炎克雷伯菌毒力和生物膜形成的机制研究,2021/01-2023/12,24万,主持
(2)mg4355线路检测官网纵向科研类/校级人才启动经费,RZ2300004369,条件致病菌群体基因组学和耐药机制研究,2023/04-2028/03,50万,主持
(3)国家重点研发计划政府间/港澳台重点专项,2018YFE0102400,耐药革兰阴性菌感染快速诊断和智能优化治疗方案的研究,2019/07-2023/07,969万,参与
(4)“十三五”国家重点研发计划项目,2017YFC1600100,重要食源性致病菌耐药机制及传播规律研究,2018/01-2021/12,2980万元,参与
代表性成果
Kuang D*, Liu F*,Tian S*, et al. Newly identified Burkholderia semiarida: A Cause of Recurrent Pulmonary Infection in An Immunocompetent Patient[J]. Emerging Infectious Diseases, (2024.3.29 accepted).
Poirier1 AC*, Kuang D*, Siedler BS*, et al. Development of Loop Mediated Isothermal amplification rapid diagnostic assays for the detection of Klebsiella pneumoniae and Carbapenemase genes in clinical samples[J]. Frontiers in Molecular Biosciences, 2022;8:794961.
Kuang D, Zhang J, Xu X, et al. Emerging high-level ciprofloxacin resistance and molecular basis of resistance in Salmonella enterica from humans, food and animals[J]. International Journal of Food Microbiology, 2018, 280: 1-9.
Kuang D, Zhang J, Xu X, et al. Increase in Ceftriaxone Resistance and Widespread of ESBLs Genes among Salmonella enterica from Human and Nonhuman Sources [J]. Foodborne Pathogens and Disease, 2018, 15(12): 770-775.
Kuang D, Xu X, Meng J, et al. Antimicrobial susceptibility, virulence gene profiles and molecular subtypes of Salmonella Newport isolated from humans and other sources[J]. Infection, Genetics and Evolution, 2015, 36: 294-299.
Kuang D, Zhang J, Meng J, et al. Antimicrobial susceptibility and molecular typing of salmonella agona isolated from humans and other sources[J]. Foodborne Pathogens and Disease, 2014, 11(11): 844-849.
Chen Z, Kuang D, Xu X, et al. Genomic analyses of multidrug-resistant Salmonella Indiana, Typhimurium, and Enteritidis isolates using MinION and MiSeq sequencing technologies[J]. PLoS One. 2020;15(7):e0235641.
Zhan Z, Kuang D, Liao M, et al. Antimicrobial Susceptibility and Molecular Typing of Salmonella Senftenberg Isolated from Humans and Other Sources in Shanghai, China, 2005 to 2011[J]. Journal of Food Protection, 2016, 80(1): 146-150.
Zhang J, Kuang D, Wang F, et al. Turtles as a Possible Reservoir of Nontyphoidal Salmonella in Shanghai, China[J]. Foodborne Pathogens and Disease, 2016, 13(8): 428-433.
Yang X, Kuang D, Meng J, et al. Antimicrobial resistance and molecular typing of Salmonella stanley isolated from humans, foods, and environment[J]. Foodborne Pathogens and Disease, 2015, 12(12): 945-949.
Cao G, Zhao S, Kuang D, et al. Geography shapes the genomics and antimicrobial resistance of Salmonella enterica Serovar Enteritidis isolated from humans[J]. Scientific Reports, 2023, 13(1): 1331.