Berthold Hocher简历
1、Prof. Med, Dr. Berthold Hocher,男,1962年6月
(1)职位:海德堡大学曼海姆医学中心医学部实验和转化医学部 主任
(2)履历:
柏林德国国家医学研究所(IFLb)科学主任和医生。
(3)学术贡献:
1)德国国家自然科学基金:
1. Grant number: DFG Ho 1665- 2-1; Name: Development and initial characterization of ET-1transgenic mice.
2. Grant number: DFG Ho 1665- 2-2 Name: Molecular Pathways of kidney injury in ET-1 transgenic mice.
3. Grant number: DFG Ho 1665- 3-1Name:Endothelin Receptor antagonists for the treatment of acute lung injury.
4. Grant number: DFG Ho 1665- 4-1Name: Endothelin Receptor antagonists for the treatment of diabetic and non-diabetic CKD.
2)中德科学中心(中国国家自然科学基金委员会/德国国家自然科学基金委员会):
合同号:M-0526 2022年 项目名称: Mechanisms of SGLT2i on cardio-renal syndrome and the regulatory network of cardio-blood-renal axis.
3) 研究领域:
国际知名心血管-肾病学研究专家,欧洲最早从事健康与内科学疾病的发育起源学说的研究专家之一,是欧洲最早从事健康和疾病的发育起源(DOHaD,都哈)学说的研究专家。胎儿遗传,心脏、肾脏及内分泌疾病的新型药物的研究以及生物标记物的研究。获得德国自然科学研究基金5项, 欧洲研究基金2项,已发表SCI收录的文章近300篇,总IF:1641.3,总引用次数:5575,总H-指数:38。其中有87篇论文发表在顶级期刊中, 如Lancet,Nature Rev Nephrol, Kidney Int, Circulation, JAMA,PNAS,Diabetologia,Nat Genet。在德国肾脏病及内分泌学科享有盛誉。
(4)主要代表性文章:
1. Hocher B, Slowinski T, Stolze T, Pleschka A, Neumayer HH, Halle H. Association of maternal G protein ß3 subunit 825T allele with low birthweight. Lancet, 355; 1241-1242 (2000)
2. Fischereder M, Luckow M, Hocher B, Wüthrich RP, Rothenpieler U, Schneeberger H, Panzer U, Stahl R, Neumayer HH, Hauser IA, Budde K, Neumayer HH, Krämer BK, Land W, Schlöndorff D. Prolongation of renal transplant survival in patients lacking a functional CC chemokine receptor 5 (CCR5). Lancet 357; 1758-1761 (2001)
3. Tsuprykov O, Ando R, Reichetzeder C, von Websky K, Antonenko V, Sharkovska Y, Chaykovska L, Rahnenfuhrer J, Hasan AA, Tammen H, Alter M, Klein T, Ueda S, Yamagishi S, Okuda S, Hocher B. The DPP4 inhibitor Linagliptin and the angiotensin II receptor blocker telmisartan show renal benefit by different pathways in non-diabetic rats with 5/6 nephrectomy. Kidney International, 2016 May;89(5):1049-61. doi: 10.1016/j.kint.2016.01.016. (2016)
4. Hocher B, Adamski J. Metabolomics for clinical use and research in chronic kidney disease. Nature Rev Nephrol. 2017 Mar 6. doi: 10.1038/nrneph.2017.30. (2017)
5. Hocher B .Hasan AA, von Websky K. Mechanisms of GLP-1 receptor-independent renoprotective effects of the dipeptidyl peptidase type 4 inhibitor linagliptin in GLP-1 receptor knockout mice with 5/6 nephrectomy. Kidney International. 2019 Jun; doi: 10.1016/j.kint.2019.01.010. Epub 2019 Feb 27.